7,210 research outputs found

    Effects of Changes in Surface Water Regime and/or Land Use on the Vertical Distribution of Water Available for Wetland Vegetation: Dynamic Model of the Zone of Aeration (Part 1 of Completion Report for Project A-023-ARK)

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    A mathematical model by Green, simulating one-dimensional vertical ground-water movement in unsaturated soils of the prairie region of Kansas, has been adapted for use in a wetlands environment typified by the wetlands forest of Eastern Arkansas. The model consists of two second-order, non-linear, partial differential equations and an algorithm for their numerical solution. The original model was extended to include functions for seasonal changes in transpiration and for drainage of excess precipitation. Before the addition of the two functions, the model reliability was limited to one growth season

    Antibodies to acetylcholine receptor in parous women with myasthenia: evidence for immunization by fetal antigen

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    The weakness in myasthenia gravis (MG) is mediated by autoantibodies against adult muscle acetylcholine receptors (AChR) at the neuromuscular junction; most of these antibodies also bind to fetal AChR, which is present in the thymus. In rare cases, babies of mothers with MG, or even of asymptomatic mothers, develop a severe developmental condition, arthrogryposis multiplex congenita, caused by antibodies that inhibit the ion channel function of the fetal AChR while not affecting the adult AChR. Here we show that these fetal AChR inhibitory antibodies are significantly more common in females sampled after pregnancy than in those who present before pregnancy, suggesting that they may be induced by the fetus. Moreover, we were able to clone high-affinity combinatorial Fab antibodies from thymic cells of two mothers with MG who had babies with arthrogryposis multiplex congenita. These Fabs were highly specific for fetal AChR and did not bind the main immunogenic region that is common to fetal and adult AChR. The Fabs show strong biases to VH3 heavy chains and to a single Vk1 light chain in one mother. Nevertheless, they each show extensive intraclonal diversification from a highly mutated consensus sequence, consistent with antigen-driven selection in successive steps. Collectively, our results suggest that, in some cases of MG, initial immunization against fetal AChR is followed by diversification and expansion of B cells in the thymus; maternal autoimmunity will result if the immune response spreads to the main immunogenic region and other epitopes common to fetal and adult AChR

    Biaxial fatigue loading of notched composites

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    Thin walled, 2.54-cm (1-in.) diameter tubular specimens of T300/934 graphite/epoxy were fabricated and fatigue cycled in combinations of axial, torsional, and internal pressure loading. Two different four-ply layup configurations were tested: (0/90)S and (+ or - 45)S; all tubes contained a 0.48-cm (3/16-in.) diameter circular hole penetrating one wall midway along the tube length. S-N curves were developed to characterize fatigue behavior under pure axial, torsional, or internal pressure loading, as well as combined loading fatigue. A theory was developed based on the Hill plane stress model which enabled the S-N curve for combined stress states to be predicted from the S-N data for the uniaxial loading modes. Correlation of the theory with the experimental data proved to be remarkably good

    Experimental investigation and modeling of dynamic performance of wave springs

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    This paper investigates vibration suppression potentials for a novel frictional system - a wave spring. Two different types of wave springs, crest-to-crest and nested ones, were used in this work. Compared with nested wave springs, crest-to-crest wave springs have lower damping and a larger range for the linear stiffness due to a reduced level of contact. Dynamic compressive tests, subject to different static compression levels, are carried out to investigate the force-displacement hysteresis of individual wave springs. The stiffness is shown to increase up to 800% when the static compression is at 40%. The crest-to-crest wave spring is shown to provide loss factors up to 0.12 while nested ones as high as 0.80. Testing also showed that performance did not degrade between room temperature and 100°C. The effect of different spring materials, inner diameter and flat spring width are also evaluated

    Nonlinear Robust Observer Design Using An Invariant Manifold Approach

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    This paper presents a method to design a reduced order observer using an invariant manifold approach. The main advantages of this method are that it enables a systematic design approach, and (unlike most nonlinear observer design methods), it can be generalized over a larger class of nonlinear systems. The method uses specific mapping functions in a way that minimises the error dynamics close to zero. Another important aspect is the robustness property which is due to the manifold attractivity: an important feature when an observer is used in a closed loop control system. A two degree-of-freedom system is used as an example. The observer design is validated using numerical simulation. Then experimental validation is carried out using hardware-in-the-loop testing. The proposed observer is then compared with a very well known nonlinear observer based on the off-line solution of the Riccati equation for systems with Lipschitz type nonlinearity. In all cases, the performance of the proposed observer is shown to be very high

    A national scale inventory of resource provision for biodiversity within domestic gardens

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    The human population is increasingly disconnected from nature due to urbanisation. To counteract this phenomenon, the UK government has been actively promoting wildlife gardening. However, the extent to which such activities are conducted and the level of resource provision for biodiversity (e.g., food and nesting sites) within domestic gardens remains poorly documented. Here we generate estimates for a selection of key resources provided within gardens at a national scale, using 12 survey datasets gathered across the UK. We estimate that 22.7 million households (87% of homes) have access to a garden. Average garden SiZe is 190 m(2), extrapolating to a total area of 432,924 ha. Although substantial, this coverage is still an order of magnitude less than that of statutory protected areas. Approximately 12.6 million (48%) households provide supplementary food for birds, 7.4 million of which specifically use bird feeders. Similarly, there are a minimum of 4.7 million nest boxes within gardens. These figures equate to one bird feeder for every nine potentially feeder-using birds in the UK, and at least one nest box for every six breeding pairs of cavity nesting birds. Gardens also contain 2.5-3.5 million ponds and 28.7 million trees, which is just under a quarter of all trees occurring outside woodlands. Ongoing urbanisation, characterised by increased housing densities, is inevitable throughout the UK and elsewhere. The important contribution domestic gardens make to the green space infrastructure in residential areas must be acknowledged, as their reduction will impact biodiversity conservation, ecosystem services, and the well-being of the human population
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